Ni izihe mpamvu zitera psoriasis?

Impamvu zitera psoriasis zirimo genetique, immunite, ibidukikije nibindi bintu, kandi indwara zayo ntizirasobanuka neza.

 1. Ibintu bikomokaho

Ubushakashatsi bwinshi bwerekanye ko ibintu bikomoka ku ngirabuzima fatizo bigira uruhare runini mu gutera indwara ya psoriasis. Amateka y’indwara afite 10% kugeza 23.8% by’abarwayi mu Bushinwa na 30% mu bihugu by’amahanga.Amahirwe yo kubyara umwana urwaye psoriasis ni 2% niba nta mubyeyi ufite iyi ndwara, 41% niba ababyeyi bombi bafite iyo ndwara, na 14% niba umubyeyi umwe afite iyo ndwara.Ubushakashatsi bwakozwe ku mpanga zifitanye isano na psoriasis bwerekanye ko impanga ya monozygotique ifite amahirwe angana na 72% yo kwandura icyarimwe kandi impanga ya dizygotic ifite 30% yo kwandura icyarimwe. Kurenga 10 byitwa susceptibility loci byagaragaye bifitanye isano cyane niterambere rya psoriasis.

2. Impamvu z'umubiri

 Gukora bidasanzwe kwa T-lymphocytes no kwinjira muri epidermis cyangwa dermis nibintu byingenzi biranga patrophysiologique ya psoriasis, byerekana uruhare rwumubiri w’umubiri mu iterambere no gutera imbere kwindwara.Ubushakashatsi buherutse gukorwa bwerekanye ko IL-23 yakozwe na selile dendritic nizindi selile zerekana antigen (APCs) itera gutandukanya no gukwirakwizwa kwa CD4 + umufasha T lymphocytes T, selile Th17, hamwe na selile Th17 ikuze ishobora gusohora ibintu bitandukanye bya Th17 bisa na selile. nka IL-17, IL-21, na IL-22, zitera ikwirakwizwa ryinshi rya selile ikora keratine cyangwa igisubizo cya selile ya synovial. Kubwibyo, Th17 selile hamwe na IL-23 / IL-17 axis irashobora kugira uruhare runini mugutera indwara ya psoriasis.

3. Ibidukikije na Metabolic Ibintu

Ibintu bidukikije bigira uruhare runini mu gukurura cyangwa gukaza psoriasis, cyangwa mu kongera indwara, harimo kwandura, guhangayika mu mutwe, ingeso mbi (urugero, kunywa itabi, ubusinzi), ihahamuka, ndetse n’imyitwarire y’imiti imwe n'imwe.Intangiriro yo gutera psoriasis akenshi iba ifitanye isano n'indwara ikaze ya streptococcale yandura, kandi kuvura anti-infection bishobora gutera gutera imbere no kugabanuka cyangwa gukira ibikomere byuruhu. Guhangayika mu mutwe (nko guhangayika, kubura ibitotsi, gukora cyane) birashobora gutera psoriasis kubaho, kwiyongera cyangwa kwisubiramo, kandi gukoresha imiti ivura ibitekerezo bishobora kugabanya indwara. Usanga kandi hypertension, diyabete, hyperlipidemiya, indwara zifata imitsi ya coronari na syndrome de metabolike yiganje cyane mu barwayi ba psoriasis.