Ni izihe mpamvu zitera psoriasis?

Impamvu zitera psoriasis zirimo ibintu bigize imiterere y’umubiri, ubudahangarwa bw’umubiri, ibidukikije n’ibindi, kandi imiterere yayo ntabwo irasobanuka neza.

 1. Ibintu bitera imiterere y'umubiri (genetic factors)

Ubushakashatsi bwinshi bwagaragaje ko ibintu bigize imiterere y’umubiri bigira uruhare runini mu gutera psoriasis. Amateka y’iyi ndwara mu muryango agira uruhare runini hagati ya 10% na 23.8% by’abarwayi mu Bushinwa na hafi 30% mu bihugu by’amahanga.Amahirwe yo kubyara umwana urwaye psoriasis ni 2% niba nta mubyeyi n'umwe urwaye iyi ndwara, 41% niba ababyeyi bombi bayirwaye, na 14% niba umwe mu babyeyi bayirwaye.Ubushakashatsi ku mpanga zifitanye isano na psoriasis bwagaragaje ko impanga zigizwe na monozygotic zifite amahirwe angana na 72% yo kurwara indwara icyarimwe naho impanga zigizwe na dizygotic zifite amahirwe angana na 30% yo kurwara indwara icyarimwe. Hagaragajwe ko ahantu harenga 10 hazwi nka susceptibility locis bifitanye isano rikomeye n’iterambere rya psoriasis.

2. Ibintu bitera ubudahangarwa bw'umubiri

 Gukora ku buryo budasanzwe kwa limfu za T no kwinjira mu gice cy’imbere cy’uruhu cyangwa uruhu ni ibintu by’ingenzi bigaragaza ko psoriasis igira uruhare mu iterambere n’iterambere ry’indwara.Ubushakashatsi buherutse bwerekanye ko ikorwa rya IL-23 n'uturemangingo twa dendritic n'utundi turemangingo twigaragaza antigen (APCs) rituma habaho itandukaniro no kwiyongera kwa lymphocytes T helper CD4+, uturemangingo twa Th17, hamwe n'uturemangingo twa Th17 dukuze dushobora gusohora ibintu bitandukanye bisa na Th17 nka IL-17, IL-21, na IL-22, bitera kwiyongera cyane kwa uturemangingo dukora keratin cyangwa se ingaruka zo kubyimba kwa uturemangingo twa synovial. Kubwibyo, uturemangingo twa Th17 hamwe n'umurongo wa IL-23/IL-17 bishobora kugira uruhare runini mu gutera psoriasis.

3. Ibintu bifitanye isano n'ibidukikije n'imikorere ya metabolike

Ibintu bidukikije bigira uruhare runini mu gutera cyangwa kongera ubwiyongere bw'indwara ya psoriasis, cyangwa mu gutuma iyi ndwara ikomeza, harimo indwara zandura, imihangayiko yo mu mutwe, ingeso mbi (urugero: kunywa itabi, kunywa inzoga nyinshi), ihungabana, n'ingaruka ku miti imwe n'imwe.Gutangira kwa psoriasis ifata imiyoboro y'amaraso akenshi bifitanye isano no kwandura indwara z'uruhu mu buryo bukabije, kandi uburyo bwo kuvura indwara zishobora gutuma ibisebe by'uruhu birushaho kuba byiza no kugabanya cyangwa bigabanura. Imihangayiko yo mu mutwe (nk'imihangayiko, ibibazo byo gusinzira, gukora cyane) bishobora gutuma psoriasis ibaho, irushaho gukomera cyangwa ikagaruka, kandi gukoresha uburyo bwo kuvura indwara zo mu mutwe bishobora koroshya iyo ndwara. Byagaragaye kandi ko umuvuduko ukabije w'amaraso, diyabete, hyperlipidemia, indwara z'imitsi y'umutima cyane cyane indwara ya metabolike bikunze kugaragara mu barwayi ba psoriasis.